Well-packed columns, in which the beds are homogeneous and continuous from top to bottom, exhibit the best chromatographic separations. When transferring a downstream process, it's critical to maintain as many control parameters as possible including preparation procedures. Column packing for manufacturing has historically required drastically divergent procedures compared to laboratory scale, which can lead to wide variability in chromatographic beds. Furthermore, the ever-expanding catalog of chromatography media can require highly specialized techniques for packing.
Procedures for packing chromatography columns should be scalable and reproducible as well as flexible in order to allow for modifications to support various types of chromatography media. Bio-Rad InPlace columns are designed to suit packing needs for pilot and manufacturing scale, and the packing protocols are directly scalable because the media bed is consolidated uniformly using axial compression.
Join us in this technical discussion of current challenges and solutions for column packing and how Bio-Rad InPlace columns provide ease-of use and reproducible performance for process columns.
The Audience Will Learn:
Common types of chromatography columns for downstream processing
What is Dynamic Axial Compression?
Packing pressure vs axial compression pressure
How to develop packing methods for resins with unusual attributes
Scalability of packing procedures
Reproducibility of packing performance
Webinar Presenter: Kimberly C. Brisack, Manager, Process Chromatography Applications Laboratory, Bio-Rad Laboratories
Kimberly C. Brisack is the Manager of the Process Chromatography Applications Laboratory for Bio-Rad Laboratories in Hercules, California. She attended the University of California at Berkeley for undergraduate and graduate school.
Kim spent eleven years in biotechnology, where she held several positions including downstream manufacturing and validation, purification process development and manufacturing support. She has been involved in multiple aspects of pharma development and manufacturing, including process optimization, process and cleaning validations, and technology transfer.
Kim joined Bio-Rad in 2007 and her work has centered on process scale column packing methodologies and scale-up behavior of chromatography media.
Chromatography Column Packing for Manufacturing: The Benefits of Dynamic Axial Compression
Thursday, September 13, 2012
10:00 am (ET)
11:00 am (ET)
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