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Protein Aggregation, Stability & Solubility


Reduce Protein Degradation and Safeguard your Product's Efficacy

June 04-06, 2014
Grand Hyatt Hotel
San Francisco, CA

Event Overview

Event Overview

Event Wrap-Up

Thank you to our attendees and speakers for bringing their excitement, energy, and expertise to the inaugural Protein Aggregation, Stability & Solubility conference in 2014 in San Francisco. Throughout the three days of learning, one theme rang true over and again:

"We cannot accurately predict protein aggregation. It's something we need to work on," said keynote speaker Wei Wang, Ph.D., a research fellow at Pfizer, Inc. (the conference's gold sponsor).

Despite modeling, data analytics, high-tech instruments, and other predictive efforts, the core problem of aggregation remains difficult to solve. However, many of our presenters offered tips for, and glimpses into, how to stay ahead of these challenges.

Speaking before a standing-room only crowd, Peter Tessier - associate professor at the Isermann Department of Chemical & Biological Engineering at Rensselaer Polytechnic Institute - showed attendees his work in engineering aggregation-resistant antibody fragments.

"At Protein Aggregation, I enjoyed the scientific engagement and networking opportunities." - Mohan Srinivasan, Ph.D., Director, Protein Chemistry, Molecular and Stability Sciences, Bristol-Myers Squibb Company

Meanwhile, Dimiter "Mitko" Dimitrov, a senior investigator with the U.S. National Cancer Institute, dove into aggregation concerns with antibody drug conjugates (ADCs). Expect the ADC tie-in to be featured more prominently in our program upcoming 2015 agenda.

David James, Ph.D., a professor of chemical and biological engineering from the University of Sheffield, proved adept at switching roles during our Protein Aggregation program. He went from speaking to moderating an informal brainstorming session, to later serving as chairman on our final day - and he also squeezed in a site visit to nearby Genentech, Inc.

It wasn't all work. Attendees got a chance to unwind on Pier 39 along San Francisco Bay for an evening reception at Players Sports Grill, in a bar that resembled a tiki house. We can confirm that several speakers also have Ph.D. credentials in hoops and skee ball.

Hearty thanks must also go out to Ted Randolph, professor of chemical and biological engineering at the University of Colorado, Boulder, for his chairman duties during our first two days of the event.

We hope to see everyone back in San Francisco in 2015 for our next Protein Aggregation event.

"It's hard to keep up with all of the advances in characterizing and limiting protein aggregation, and this seems like a great venue to hear about it." - Kristin B. O'Berry, M.S., Associate Scientist II, Formulation Sciences, MedImmune, LLC